IP3and Ca2+signals in the heart: boost them or bust them?

Wear them, forget them.

Off-label prescriptions: how to identify them, frame them, announce them and monitor them in practice?

Following the Mediator crisis and the passage of the Health and Safety Law of December 2011, off-label prescriptions are a real concern shared by all those involved in healthcare system. Off-label, in the strictest sense of the term, is defined as all prescriptions that do not correspond to the summary of product characteristics (SPC), particularly those that fail to comply with the indications...

Adjustable sutures in strabismus surgery: why surgeons either love them or hate them after three decades.

Strabismus surgeons continually seek to achieve the best results from their surgery, which means stable motor alignment and sensory improvement with a minimum number of procedures. But the tables and algorithms that we employ for the number of muscles to be included in the surgery, and for the doses of surgery, are often not appropriate for difficult or unpredictable cases. The ability to modif...

Beat them or ban them: the characteristics and social functions of anger and contempt.

This article reports 3 studies in which the authors examined (a) the distinctive characteristics of anger and contempt responses and (b) the interpersonal causes and effects of both emotions. In the 1st study, the authors examined the distinction between the 2 emotions; in the 2nd study, the authors tested whether contempt could be predicted from previous anger incidents with the same person; a...

Build them up and break them down

Tight junctions (TJs) of cells expressing simple epithelial polarity have been extensively studied, but less is known about TJs of cells expressing complex polarity. In this paper we analyzed, TJs of four different lines, that form bile canaliculi (BC) and express typical hepatocyte polarity; WIF-B9, 11-3, Can 3-1, Can 10. Striking differences were observed in claudin expression. None of the ce...